BOINC is an open-source volunteer oriented computing grid that combines the processing power of all individual users for the purposes of scientific research. Its free, and harnesses the unused clock cycles from processors and graphics cards to aid in curing disease, exploring the mysteries of the universe, and more.
The research team behind the Help Fight Childhood Cancer project has just published a groundbreaking paper.
It reveals seven promising drug candidates (identified with the help of World Community Grid members) for neuroblastoma, one of the most common and dangerous forms of childhood cancer.
The Help Fight Childhood Cancer research team at the Chiba Cancer Center in Japan has discovered drug candidates that show great promise as new treatments for neuroblastoma, one of the most common and dangerous forms of childhood cancer. This breakthrough marks one of the most significant scientific discoveries to date for World Community Grid.
Thanks to the contribution of over 200,000 World Community Grid members, the researchers were able to screen three million compounds and identify seven that destroy neuroblastoma tumors in mice without causing any apparent side effects.
The Chiba team plans to partner with a pharmaceutical company for further development, while also expanding their future work on World Community Grid to address other forms of childhood cancer.
In this blog post DR. Akira Nakagawara, who leads the research team at Chiba, explains the significance of this exciting finding and its potential implications on treatments for other forms of cancer.
Einstein@Home volunteers find four cosmic lighthouses in data from NASA's Fermi Gamma-ray Space Telescope.
The combination of globally distributed computing power and innovative analysis methods proves to be a recipe for success in the search for new pulsars.
Scientists from the Max Planck Institutes for Gravitational Physics and Radio Astronomy together with international colleagues have now discovered four gamma-ray pulsars in data from the Fermi space telescope.
The breakthrough came using the distributed computing project Einstein@Home, which connects more than 200,000 computers from 40,000 participants around the world to a global supercomputer.
The discoveries include volunteers from Australia, Canada, France, Germany, Japan, and the USA.
Thanks to World Community Grid volunteers, Harvard has published data about the suitability of 2.3 million organic compounds for converting sunlight into electricity.
In a press release today, Harvard researchers launched a free database (www.molecularspace.org) that catalogues 2.3 million organic, carbon-based compounds with potential for use in solar cells.
As part of The Clean Energy Project, the electronic properties of these compounds have been analyzed to determine which ones may be viable candidates for converting sunlight to electricity.
Scientists around the world can now use Harvard's database to continue investigating the most promising candidates.
It can be used to help advance the development of efficient, inexpensive organic semiconductors, and ultimately, electricity-generating devices such as solar cells.
To study the feasibility of automating tissue microarray analysis, we partnered with IBM's World Community Grid in 2006 to launch the Help Defeat Cancer project. At the time, we were pioneering a new approach that nobody else was investigating, and it was met with tremendous skepticism by many of our colleagues.
However, with the support of more than 200,000 World Community Grid volunteers from around the globe who donated over 2,900 years of their computing time, we were able to study over 100,000 patient tissue samples to search for cancer signatures.
Access to this vast computing power enabled our team to rapidly conduct this research under a much wider range of environmental conditions and to perform specimen analysis at much greater degrees of sensitivity.
Dengue fever, also known as “breakbone fever”, causes excruciating joint and muscle pain, high fever and headaches. Severe dengue, known as “dengue hemorrhagic fever”, has become a leading cause of hospitalization and death among children in many Asian and Latin American countries. According to the World Health Organization (WHO), over 40% of the world’s population is at risk from dengue; another study estimated there were 390 million cases in 2010 alone.
We have recently made an exciting discovery using insights from Discovering Dengue Drugs - Together to guide additional calculations on our web portal for advanced computer-based drug discovery, DrugDiscovery@TACC. A molecule has demonstrated success in binding to and disabling a key dengue enzyme that is necessary for the virus to replicate.
Furthermore, it also shows signs of being able to effectively disable related flaviviruses, such as the West Nile virus. Importantly, our newly discovered drug lead also demonstrates no negative side effects such as adverse toxicity, carcinogenicity or mutagenicity risks, making it a promising antiviral drug candidate for dengue and potentially other flavivirues. We are working with medicinal chemists to synthesize variants of this exciting candidate molecule with the goal of improving its activity for planned pre-clinical and clinical trials.
Since launching on World Community Grid in 2008, The Clean Energy Project has screened more than two million organic molecules, with the help of our volunteers – the most extensive investigation of quantum chemicals ever performed. These results were made available to other researchers and the public last summer as part of President Obama’s Materials Genome Initiative – a public-private collaborative effort to double the pace of high-tech materials development. The White House praised The Clean Energy Project and highlighted the crucial role it plays in advancing materials science.
So far, more than 35,000 of the compounds analyzed on World Community Grid show the ability to perform at approximately double the efficiency of most organic solar cells in production today. Before this initiative, scientists knew of just a handful of carbon-based materials that were able to convert sunlight into electricity efficiently. The Harvard team – who so far have been provided with the equivalent of 17,000 years of computing time – continues to investigate the most promising candidates for use in cheaper, more efficient and flexible solar cells.
Projects like this require a massive amount of computing power – and the more volunteers we have contributing, the faster this vital research can be completed.